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José L Neira Selected Research

Inosine Diphosphate (IDP)

10/2021Design of Inhibitors of the Intrinsically Disordered Protein NUPR1: Balance between Drug Affinity and Target Function.
2/2021Intrinsically disordered protein NUPR1 binds to the armadillo-repeat domain of Plakophilin 1.
11/2019Dynamics of the intrinsically disordered protein NUPR1 in isolation and in its fuzzy complexes with DNA and prothymosin α.
1/2019Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis.
1/2018The chromatin nuclear protein NUPR1L is intrinsically disordered and binds to the same proteins as its paralogue.
1/2018Amphipathic helical peptides hamper protein-protein interactions of the intrinsically disordered chromatin nuclear protein 1 (NUPR1).
8/2017Intrinsically disordered chromatin protein NUPR1 binds to the C-terminal region of Polycomb RING1B.
1/2017Identification of a Drug Targeting an Intrinsically Disordered Protein Involved in Pancreatic Adenocarcinoma.
1/2016Determinants of the pKa values of ionizable residues in an intrinsically disordered protein.

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José L Neira Research Topics

Disease

13Neoplasms (Cancer)
01/2022 - 05/2002
4Pancreatic Neoplasms (Pancreatic Cancer)
01/2019 - 08/2010
3Pancreatitis
11/2019 - 01/2018
3Adenocarcinoma
01/2019 - 01/2017
3Infections
08/2013 - 11/2009
2Neoplasm Metastasis (Metastasis)
01/2019 - 09/2011
2Carcinogenesis
08/2017 - 11/2007
1Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy)
01/2021
1Inborn Genetic Diseases (Disease, Hereditary)
03/2019
1Mitochondrial Diseases (Mitochondrial Disease)
11/2016
1Breast Neoplasms (Breast Cancer)
09/2011

Drug/Important Bio-Agent (IBA)

10Proteins (Proteins, Gene)FDA Link
01/2022 - 11/2003
9Intrinsically Disordered ProteinsIBA
10/2021 - 01/2017
9Inosine Diphosphate (IDP)IBA
10/2021 - 01/2016
5Pharmaceutical PreparationsIBA
10/2021 - 01/2016
2Biological ProductsIBA
10/2021 - 01/2019
2NUPR1 inhibitor ZZW-115IBA
01/2020 - 01/2019
1Peptides (Polypeptides)IBA
01/2021
1TropomyosinIBA
01/2021
1Nuclear Proteins (Protein, Nuclear)IBA
01/2020
1Heat-Shock Proteins (Heat-Shock Protein)IBA
01/2020
1ProteomeIBA
03/2019
1EnzymesIBA
03/2019
1FlavoproteinsIBA
03/2019
1Flavin-Adenine Dinucleotide (FAD)IBA
03/2019
1Trifluoperazine (Stelazine)FDA LinkGeneric
01/2019
1Antipsychotic Agents (Antipsychotics)IBA
01/2019
1ChromatinIBA
01/2018
1CytokinesIBA
08/2013
1ChemokinesIBA
08/2013
1Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA
09/2011
1DNA (Deoxyribonucleic Acid)IBA
08/2010
1FlavodoxinIBA
11/2009
1Antiviral Agents (Antivirals)IBA
11/2009
1Polycomb Repressive Complex 1IBA
11/2007
1Protein Subunits (Protein Subunit)IBA
11/2007
1Tumor Protein p73IBA
05/2002